Dr. Terry Hamblin la LLC dans son blog Pronostiqueurs

Pronostiqueurs
*2011*mutations of mortality: TP53 again: "WE know that TP53 problems are about the worst you can have with CLL, but we also know that 17p deletion is very rare in newly diagnosed pat..."
*2008*mutations of mortality: TP53: is it such a big deal?: "Everyone knows that p53 abnormalities bode ill for patients with CLL. Generally such leukemias are resistant to fludarabine, cyclophosphamid..."
*2009*mutations of mortality: P53 explored: "Of all the malign features of CLL, damage to the p53 pathway is the most serious. Most drugs used in CLL work by invoking the p53 pathway to..."
*2007*mutations of mortality: Hope for p53 mutants: "The worst cases of CLL are those with reduced or absent p53 function. There are two reasons for this. p53 is known as ‘the guardian of the g..."

*2011*mutations of mortality: ZAP-70 again: "As readers know I am less than enthusiastic about ZAP-70 as a surrogate for IGHV mutations. I came across this conversation on the web which..."
*2010*mutations of mortality: ZAP-70 changes: "In order to make this paper available to all. ZAP-70 levels do change in CLL but not very often.Terry J Hamblin Abstract Evidence is accum..."
*2007*mutations of mortality: ZAP-70 again.: "One of the most pressing topics to come up in Canada was the usefulness or otherwise of ZAP-70 as a prognostic factor. In fact John Byrd sai..."
*2007*mutations of mortality: ZAP-70: "ZAP-70 is a molecule used to transmit a signal from the T-cell receptor to downstream pathways. Most B cells lack ZAP-70 and instead use a r..."


*2010*mutations of mortality: More on 13q14: "I have been promising to write something more about the 13q14 deletion in CLL. I have already visited this subject several times and claim s..."
*2010*mutations of mortality: A del 13q anomaly explained: "After Carlo Croce stressed the importance of the miR-15 and 16 genes in del 13q14 CLL we had a bit of problem because the smallest minimally..."
*2010*mutations of mortality: Del 13q14 - the Bournemouth background: "I feel a sort of ownership for del 13q14, since it was on some of my patients that the first cases in both CLL and myeloma that it was disco..."

*2011*mutations of mortality: Alkylating agents for del 11q: "I am sure you will recognise the Dohner et al hierarchical model for FISH results in CLL. This graph has been published hundreds of times. ..."
*2007*mutations of mortality: Del 11q23: "I am responding to one of my correspondents up front because not everybody reads the 'comments' on this blog. 'Anonymous' has misinterpreted..."



*2008*mutations of mortality: CD38 polymorphisms: "Why are we all so different? The plain answer is genetic polymorphisms. Perhaps the best known example is sickle cell anemia. Most people ha..."
*2007*mutations of mortality: Up to date on CD38: "Readers may have noticed that I have not yet delivered my promised summary of the IWCLL meeting. This is because I have been working on one ..."
*2005*mutations of mortality: CLLs discordant for VH mutations and CD38 have an ...: "CLLs discordant for VH mutations and CD38 have an intermediate prognosis "
*2005*mutations of mortality: This was the original graph from the Chiorazzi pap...: "This was the original graph from the Chiorazzi paper showing that CD38 was a useful prognostic factor "
*2005*mutations of mortality: CD38: "Somebody recently asked on the ACOR List CD38 and VH genes interalate. Let's first think about CD38. It has been mentioned in well over 1000..."

*2008*mutations of mortality: SNIPs: "The prognostic factors of CLL are well established and include clinical stage, IgVH mutational status, CD38 expression, ZAP-70 expression (w..."

*2008*mutations of mortality: CD20 and trisomy 12: "In advice that I have been giving over the past 5 years I have been stressing that CD20 is brighter in patients who have trisomy 12. Indeed ..."

*2006*mutations of mortality: Soluble CD23: "CD23 is the low affinity receptor for IgE. When it appears on eosinophils and macrophages it helps these cells to kill and eat structures th..."

*2008*mutations of mortality: FISH and mutations: "I have recently been asked whether del 11q is also influenced by the mutational status of IgVH genes. As you can see by these two survival..."
*2006*mutations of mortality: Del 17p: "One of the most feared findings in CLL is a loss of the short arm of chromosome 17. It is usually found by FISH testing and the technical te..."

*2008*mutations of mortality: FCRL2; a new prognostic marker for CLL: "In a forthcoming issue of Blood there will be an article on FCRL2, a new prognsotic factor for CLL. The discovery that patients with chroni..."
*2005*mutations of mortality: One picture is worth a thousamd words. This surviv...: "One picture is worth a thousamd words. This survival curve shows the difference between having mutated and unmutated VH genes. "
*2005*mutations of mortality: VH mutations: "I well remember a meeting in Italy when VH gene mutations were the hot topic. I was in the camp that believed that CLL was frozen in time as..."

*2007*mutations of mortality: Beta-2 microglobulin: "I am beginning to have a different view of beta-2 microglobulin as a prognostic factor in CLL. Hitherto, I have been suspicious of its value..."
*2005*mutations of mortality: Beta-2 microglobulin: "Beta-2 microglobulin is used by some centers as a prognostic factor and is particularly favored by the MD Anderson Cancer Center in Houston...."

*2008*mutations of mortality: CLL; Assessment of prognosis: "In chronic lymphocytic leukaemia, a third of patients never need treatment and have long survival; in another third, an initial indolent pha..."

*2007*mutations of mortality: How many mutations are you allowed?: "Legend of figure. Figure 1. Comparison of survival in months of patients with CLL with different degrees of sequence homology for IgVH g..."