Dr. Terry Hamblin la LLC dans son blog

Outils de diagnostique
*2011*mutations of mortality: CT scanning in CLL: "Because CT scanning is the only way to follow what is happening in lymphoma, oncologists assume that it should be done in CLL. Nothing could..."

*2009*mutations of mortality: Elements of Danger - Medical Imaging: "An article in today's New England Journal of Medicine needs to be considered by everyone with CLL. It is probably true that patients with CL..."

*2009*mutations of mortality: Diagnosing CLL: "The diagnosis of CLL is easy, but the criteria for the diagnosis have recently changed. The first thing that is necessary is a raised lympho..."

*2005*mutations of mortality: How do you know if you have CLL?: "December 14th 2005 Three-quarters of all cases of CLL are discovered by accident. The patient has a blood test for some other reason or, th..."

Divers
*2011*mutations of mortality: Picking up on Richter's Syndrome: "What makes a CLL patient more prone to develop Richter's syndrome? This is an important question since early recognition and treatment are t..."

*2011*mutations of mortality: Leukostasis and thrombosis in CLL: "The highest white count that I have seen in CLL is 800,000/cu mm though Tom Kipps told me of a patient with 1,400,000/cu mm. The odd thing i..."

*2011*mutations of mortality: Splenic lymphomas: "My source for this article is Iannitto & Tripido, Blood 2011; 17:2585. The causes of splenomegaly are many. Infections can cause (usually t..."

*2011*mutations of mortality: The Mayo vitamin D paper: "I have now had a chance to study the paper from the Mayo Clinic that found an association between low levels of vitamin D and poor prognosis..."

*2010*mutations of mortality: vitamin D and CLL: "I wrote about vitamin D in January this year, but I am prompted to write about it again by the recent announcement by the Institute of Medic..."

** mutations of mortality: Vitamin D and cancer, particularly CLL:  "When I started my series on vitamins I intended to deal with the question of vitamin D and CLL, but I got sidetracked. I have seen a number ..."

**mutations of mortality: T-CLL: "There are a lot of people who have been told that they have T-CLL. Many years ago this was a proper diagnosis. Indeed, it was taught that th..."

*2009*mutations of mortality: The cause of CLL: "The extreme differences in geographical variation worldwide ought to give us a clue as to the etiology of CLL. Prevalence rates show a 40-fo..."

*2009*mutations of mortality: More of the CLL Chapter: "I have been gradually improving since the weekend and I have put some work in on the chapter that is due next month. Diagnosis The diagnosi..."

*2009*mutations of mortality: CLL: Introduction: "Sorry to have been silent for so long. Two things: the side effects lasted longer this time than usual; that in itself would not have stoppe..."

*2009*mutations of mortality: CLL: differential diagnosis part II: "B-PLL B-PLL is a very rare disease and some people think that it doesn’t exist as a single entity. The picture shows what it looks like do..."

*2009*mutations of mortality: CLL differential diagnosis: "The diagnosis of CLL is easy. The cells are very characteristic on the blood film. They have dark staining nuclei that takes up most of the..."

*2009*mutations of mortality: What is leukemia?: "I am in the process of writing a chapter on CLL for a new textbook and I thought I would take the opportunity to write a guide to CLL for pa..."

*2009*mutations of mortality: What is a CR?: "I spent yesterday wrestling with the CLL Guidelines - both the 1996 and the 2008 versions - trying to evaluate a clinical trial results as p..."

*2008*mutations of mortality: Merkel Cell Carcinoma: "About one third of cases of Merkel cell carcinoma occur in patients with CLL. Although second cancers reputedly occur more commonly in patie..."

*2008*mutations of mortality: CLL - MBL - IWCLL: "Earlier this year new guidelines on CLL were published by the IWCLL. I have to admit that despite being consulted about the paper before pub..."

*2008*mutations of mortality: Non Hemic Autoimmunity in CLL: "Although everyone is familiar with the autoimmune complications of chronic lymphocytic leukemia (CLL), a clear understanding of their pathog..."

*2008*mutations of mortality: Is CLL a lymphoma?: "This is one of the most frequently asked questions by patients, and the answer is yes and no. It depends on what you understand by the word ..."

*2008*mutations of mortality: CLL - is treatment getting better?: "The SEER database is a wonderful tool for understanding cancer and the recent release of hematological data from 1973 to 2004 has prompted s..."

*2008*mutations of mortality: CLL: Consolidation therapy: "Consolidation of remission aims to eliminate all detectable disease from the patient. In assessing the success of such attempts, the sensiti..."

*2008*mutations of mortality: CLL: apoptosis and proliferation: "Accumulation of mature B cells that have escaped programmed cell death and undergone cell-cycle arrest in the G0/G1 phase is the hallmark
of..."

*2008*mutations of mortality: CLL: Diagnosis and Pathophysiology: "Clinical diagnosis of chronic lymphocytic leukaemia is defined by absolute lymphocytosis of at least 5×109/L mature-appearing lymphocytes an..."

*2008*mutations of mortality: Genetic abnormalities in CLL: "Although multiple instances of chronic lymphocytic leukaemia in some families, and low frequency of the disease in individuals of Japanese o..."

*2007*mutations of mortality: Early stage treatment: "What follows is an early draft of a paper I am writing that makes the case for new trials of whether early treatment might benefit some pati..."

*2007*mutations of mortality: Leukemic Stem Cells: "The question is often asked as to whether there are leukemic stem cells for CLL. The theory goes like this. Most of the cells in a cancer ar..."

*2007*mutations of mortality: IWCLL 2007: "This week I have been at the IWCLL meeting in London. This meeting began many years ago in Paris and I have been to most of them. We were sh..."
*2006*mutations of mortality: Consultation document: "This is a draft of a paper that I am writing. I would appreciate comment from the CLL community. I have corrected some of the errors that cr..."


Théorie
*2011*mutations of mortality: More on Stereotypy: "ASH 2010 abstract 43 summarizes a collaboration between 16 different laboratories in which a total of 7596 patients with CLL who had had the..."

*2011*mutations of mortality: Autoimmunity and CLL: "Emili Montserrat's group in Barcelona has just published its experience with autoimmune phenomena in CLL over the past 28 years Blood 2010, ..."

*2011*mutations of mortality: CD14 raised in CLL: "It has long been known that CLL cells need help to be able to survive. Several studies have shown that it is what goes on in the tissues rat..."

*2011*mutations of mortality: T-depleted transplants - the UK experience: "The point about RIC transplants is that they use the transplanted immune system to attack the host's leukemia. This graft-versus-leukemia (G..."

*2011*mutations of mortality: CMV and immunosuppression: "A herpes virus isn't just for Christmas; you have it for life. This is particularly true for cytomegalo virus (CMV) which about 85% of us ge..."

*2011*mutations of mortality: LEF1: the Wnt pathway in CLL: "A paper from Neil Kay's group at the Mayo looks at LEF-1 which I mentioned in the last article as being part of the canonical Wnt signaling ..."

*2011*mutations of mortality: siRNA knockdowns of ROR1 and FMOD: "Small interfering RNAs (siRNAs) are a useful tool in finding out what genes do. Previously it was necessary to produce genetically engineere..."

*2011*mutations of mortality: array CGH: "When I started as a hematologist, I worked for a guy, who though a hematologist by name, was not much interested in patients with leukemia, ...

*2011*mutations of mortality: CCL3 - a VH surrogate: "It is now very clear that signaling through the B-cell receptor (BCR) is extremely important in determining how active CLL is. My original o..."

*2011*mutations of mortality: The cell of origin for CLL: "One of the great mysteries about CLL is what the cell of origin is. Based on its CD5 positivity it was originally thought to be derived from..."

**mutations of mortality: How does rituximab work?: "There is no doubt that rituximab was the drug of the decade as far as sufferers from lymphoid malignancies are concerned, but the big questi..."

*2009*mutations of mortality: MRD now: "In the previous article I mentioned the value of becoming MRD negative. I should stress that the method used to determine MRD negativity is ..."

*2009*mutations of mortality: The TCL1 story: "For the past couple of weeks I have been seeking to understand the TCL1 story. This is the result, though I have to confess that it is very ..."

*2009*mutations of mortality: MBL v CLL: "I have beavering away at the chapter I promised to write and have completed this section on monoclonal B-cell lymphocytosis. The references ..."

*2009*mutations of mortality: Just how common is CLL?: "Just exactly how common is CLL? Most articles about CLL begin with the sentence, “CLL is the commonest type of leukaemia in the Western wor..."

*2009*mutations of mortality: Prolymphocytes: "There has been quite a lot of discussion lately about prolymphocytes. A prolymphocyte is a lymphocyte that looks different down the micro..."

*2008*mutations of mortality: Dasatinib and CLL: "Figure from Src-family kinases in the development and therapy of Philadelphia chromosome-positive chronic myeloid leukemia and acute lympho..."

*2008*mutations of mortality: The B cell receptor: "The B-cell receptor The B-cell receptor is a multimeric complex formed by the assembly of a surface immunoglobulin homodimer and a non-cova..."

*2007*mutations of mortality: Chromosomes at IWCLL: "In my first report from the IWCLL I want to focus on chromosomes. FISH - fluorescent in-situ hybridization is the mainstay of chromosomal ex..."
*2005*mutations of mortality: Immunophenotyping: "All these CD numbers are confusing. It has nothing to do with compact discs. CD stands for clusters of differentiation. In the 1980s labora..."